RR Lyrae - Theory vs Observation

The luminosities, effective temperatures and metallicities that are derived empirically by Kovacs and Jurcsik from the light curves of a large number of globular cluster and field RRab and RRc stars are compared to theoretical RR Lyrae models. The strong luminosity dependence of the empirical blue and red edges (Log L vs Log Teff diagram) is in disagreement with that of both radiative and convective models. A reexamination of the theoretical uncertainties in the modelling leads us to conclude that the disagreement is irreconcilable.Comment: 6 pages, 5 figures (revised april 2000, revisions relatively minor

Hydrodynamical Survey of First Overtone Cepheids

A hydrodynamical survey of the pulsational properties of first overtone Galactic Cepheids is presented. The goal of this study is to reproduce their observed light- and radial velocity curves. The comparison between the models and the observations is made in a quantitative manner on the level of the Fourier coefficients. Purely radiative models fail to reproduce the observed features, but convective models give good agreement. It is found that the sharp features in the Fourier coefficients are indeed caused by the P1/P4 = 2 resonance, despite the very large damping of the 4th overtone. For the adopted mass-luminosity relation the resonance center lies near a period of 4.2d +/- 0.2 as indicated by the observed radial velocity data, rather than near 3.2d as the light-curves suggest.Comment: ApJ, 12 pages, (slightly) revise

Mode Switching Time Scales in the Classical Variable Stars

Near the edges of the instability strip the rate of stellar evolution is larger than the growth-rate of the pulsation amplitude, and the same holds whenever the star is engaged in pulsational mode switching. Stellar evolution therefore controls both the onset of pulsation at the edges of the instability strip and of mode switching inside it. Two types of switchings (bifurcations) occur. In a soft bifurcation the switching time scale is the inverse harmonic mean of the pulsational modal growth-rate and of the stellar evolution rate. In a hard bifurcation the switching times can be substantially longer than the thermal time scale which is typically of the order of a hundred periods for Cepheids and RR Lyrae. We discuss some of the observational consequences, in particular the paucity of low amplitude pulsators at the edges of the instability strip.Comment: 5 pages, 3 figures, ApJ (in press

Turbulent convection: comparing the moment equations to numerical simulations

The non-local hydrodynamic moment equations for compressible convection are compared to numerical simulations. Convective and radiative flux typically deviate less than 20% from the 3D simulations, while mean thermodynamic quantities are accurate to at least 2% for the cases we have investigated. The moment equations are solved in minutes rather than days on standard workstations. We conclude that this convection model has the potential to considerably improve the modelling of convection zones in stellar envelopes and cores, in particular of A and F stars.Comment: 10 pages (6 pages of text including figure captions + 4 figures), Latex 2e with AAS Latex 5.0 macros, accepted for publication in ApJ

RR Lyrae Variables in the Globular Cluster M55. The First Evidence for Non Radial Pulsations in RR Lyr Stars

We present the results of a photometric study of RR Lyrae variables in the field of the globular cluster M55. We have discovered nine new RR Lyrae stars, increasing the number of known variables in this cluster to 15 objects. Five of the newly discovered variables belong to Bailey type RRc and two to type RRab. Two background RRab stars are probable members of the Sagittarius dwarf galaxy. Fourier decomposition of the light curves was used to derive basic properties of the present sample of RR Lyrae variables. From an analysis of the RRc variables we obtain a mean mass of $M=0.53\pm0.03 M_\odot$, luminosity $\log L=1.75\pm0.01$, effective temperature $T_{eff}=7193\pm27$ K, and helium abundance $Y=0.27\pm0.01$. Based on the $B-V$ colors, periods and metallicities of the RRab stars we estimate the value of the color excess for M55 to be equal to $E(B-V)=0.11\pm0.03$. Using this value we derive the colors of the blue and red edges of the instability strip in M55. The blue edge lies at $(B-V)_0=0.20$ mag and the red edge lies at $(B-V)_0=0.38$ mag. We estimate the values of the visual apparent and dereddened distance moduli to be $13.65\pm0.11$ and $13.31\pm0.11$, respectively. The light curves of three of the RRc variables exhibit changes in amplitude of over 0.1 mag on the time scale of less than a week, rather short for the Blazhko effect, but with no evidence for another radial pulsational frequency. However we do detect other periodicities which are clearly visible in the light curve after removing variations with the first overtone radial frequency. This is strong evidence for the presence of non-radial pulsations, a behavior common for $\delta$ Scuti stars but not yet observed among RR Lyr variables.Comment: submitted to Astronomical Journal, 33 pages with 11 figure

Consensus of German Transplant Centers on Hematopoietic Stem Cell Transplantation in Fanconi Anemia

Allogeneic hematopoietic stem cell transplantation (HSCT) is currently the only curative therapy for the severe hematopoietic complications associated with Fanconi anemia (FA). In Germany, it is estimated that 10–15 transplants are performed annually for FA. However, because FA is a DNA repair disorder, standard conditioning regimens confer a high risk of excessive regimen-related toxicities and mortality, and reduced intensity regimens are linked with graft failure in some FA patients. Moreover, development of graft-versus-host disease is a major contributing factor for secondary solid tumors. The relative rarity of the disorder limits HSCT experience at any single center. Consensus meetings were convened to develop a national approach for HSCT in FA. This manuscript outlines current experience and knowledge about HSCT in FA and, based on this analysis, general recommendations reached at these meetings

BVI time series data of the Galactic Globular Cluster NGC3201. I. RR Lyrae stars

We present Johnson BV, and Kron-Cousins I-band time series data collected over three consecutive nights in a region of 13 arcmin^2 centered on the Galactic Globular Cluster (GGC) NGC3201. The time sampling of current CCD data allowed us to derive accurate light curves, and in turn mean magnitudes and colors for a sample of 53 RR Lyrae. To overcome the thorny problem of differential reddening affecting this cluster, we derived new empirical relations connecting the intrinsic (B-V) and (V-I) colors of fundamental ($RR_{ab}$) RR Lyrae to the luminosity amplitude, the metallicity, and the pulsation period. The key features of these relations are the following: i) they rely on stellar parameters which are not affected by reddening; ii) they supply accurate estimates of intrinsic colors across the fundamental instability strip and cover a wide metallicity range; iii) they were derived by neglecting the RR Lyrae that are affected by amplitude modulation. Moreover, the zero-point of the E(B-V) reddening scale was empirically checked using the large sample of RR Lyrae in M3 (Corwin & Carney 2001), a GGC affected by a vanishing reddening. According to these relations we estimated individual reddenings for RR Lyrae in our sample and the main results we found are the following: i) the mean cluster reddening based on E(B-V) color excesses is =0.30\pm0.03. iii) According to current individual E(B-V) and E(V-I) reddenings and theoretical predictions for Horizontal-Branch stars, we found that the true distance modulus for this cluster is 13.32\pm0.06 mag. iv) The comparison between present luminosity amplitudes and estimates available in the literature discloses that approximately 30% of fundamental RR Lyrae are affected by amplitude modulation (Blazhko effect).Comment: 36 pages, 7 tables, 18 figures, AJ in pres

Infrared Light Curves of Mira Variable Stars from COBE DIRBE Data

We have used the COBE DIRBE database to derive near- and mid-infrared light curves for a well-defined sample of 38 infrared-bright Mira variable stars, and compared with optical data from the AAVSO. In general, the 3.5 micron and 4.9 micron DIRBE bandpasses provide the best S/N light curves, with S/N decreasing with wavelength at longer wavelengths. At 25 microns, good light curves are only available for ~10 percent of our stars, and at wavelengths >= 60 microns, extracting high quality light curves is not possible. The amplitude of variability is typically less in the near-infrared than in the optical, and less in the mid-infrared than in the near-infrared, with decreasing amplitude with increasing wavelength. On average, there are 0.20 +/- 0.01 magnitudes variation at 1.25 microns and 0.14 +/- 0.01 magnitudes variation at 4.9 micron for each magnitude variation in V. The observed amplitudes are consistent with results of recent theoretical models of circumstellar dust shells around Mira variables. For a few stars in our sample, we find clear evidence of time lags between the optical and maxima of phase ~ 0.05 - 0.13, with no lags in the minima. For three stars, mid-infrared maximum appears to occur slightly before that in the near-infrared,but after optical maximum. We find three examples of secondary maxima in the rising portions of the DIRBE light curves, all of which have optical counterparts in the AAVSO data, supporting the hypothesis that they are due to shocks rather than newly-formed dust layers. We find no conclusive evidence for rapid (hours to days) variations in the infrared brightnesses of these stars.Comment: 16 pages, Astronomical Journal, in press, to be publishe

Biomarkers in T cell therapy clinical trials

T cell therapy represents an emerging and promising modality for the treatment of both infectious disease and cancer. Data from recent clinical trials have highlighted the potential for this therapeutic modality to effect potent anti-tumor activity. Biomarkers, operationally defined as biological parameters measured from patients that provide information about treatment impact, play a central role in the development of novel therapeutic agents. In the absence of information about primary clinical endpoints, biomarkers can provide critical insights that allow investigators to guide the clinical development of the candidate product. In the context of cell therapy trials, the definition of biomarkers can be extended to include a description of parameters of the cell product that are important for product bioactivity